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Stuart N. Seidman, M.D., Steven P. Roose, M.D., Matthew A. Menza, M.D., Ridwan Shabsigh, M.D., and Raymond C. Rosen, Ph.D.
Herbal Remedies: Asian ginseng and Ginkgo biloba are believed to improve erectile function in some men. However, consult a doctor before taking any herbal supplements to ensure they are safe for you to take.
Permanently alters or may injure erection bodies
By Peter West
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Currently in phase II development, Zoraxel is based on clavulanic acid and allegedly alters brain dopamine and serotonine levels, thus improving erectile function.
A. Many men and their partners don't like the device because the erection it produces is not "normal." Some pump users complain that their penis feels numb, or that it becomes discolored, misshapen, and cold to the touch. Many couples complain about the interruption of intimacy it brings to lovemaking. Also, some men complain that the constriction ring at the base of the penis causes mild discomfort upon ejaculation or varying degrees of ejaculation impairment.
"No in-vivo studies in an animal model have been performed at this regard, so a lot of work must be done. We would like to test in vivo [with animals] the molecule to understand if it really works in humans," said study lead author Mario Dell'Agli, of the University of Milan's laboratory of pharmacognosy. "At this stage of the research, we cannot say if the molecule we have synthesized possesses less side effects with respect to Viagra. However, this derivative seems to be in vitro [in lab tests] more selective than Viagra, because it targets [an enzyme involved in blood flow to the penis] more precisely."
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Causes of Impotence
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Nonpharmacologic options may be offered as second-line treatment in lieu of intraurethral or intracavernosal injection for patients who do not respond to or cannot tolerate oral therapy. Vacuum erection devices increase corporal blood flow, and a constrictor ring is then used to retain this blood within the penis. Satisfaction is variable (27%–74%), and this technique can cause discomfort and bruising of the penis.63 Surgical options exist for patients with erectile dysfunction. Penile arterial bypass surgery is appropriate in only a select group of patients (men under 35 years of age who have no generalized vascular disease and in whom an isolated injury has obstructed blood flow). Penile implants are available for patients who have not responded to more conservative treatment. This procedure is invasive, irreversible and subject to complications such as infection, erosion and mechanical failure. There is, however, a high rate of patient and partner satisfaction.63
What symptoms are associated with serious side effects or complications?
Gene therapy for erectile dysfunction is now being tested in several centers and may offer a long-lasting therapeutic approach for treating this disorder.
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